Learning objectives
- 1Describe the endocannabinoid system, cannabinoid receptor pharmacology, and the metabolism of THC and CBD.
- 2Analyze the mechanisms by which cannabis use alters GABAergic anesthetic requirements and identify the role of NMDA receptor antagonists in attenuating those effects.
- 3Evaluate cannabinoid interactions with opioids, their impact on postoperative pain and PONV, and current evidence regarding neuromuscular blockade and neuraxial anesthesia.